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ВВОДНАЯ К 1-МУ НОМЕРУ ХРОНОМЕДИЦИНСКОГО ЖУРНАЛА (JOURNAL OF CHRONOMEDICINE)
стр.3-5
Tyumen State Medical University has decided to develop former «Tyumen Medical Journal» in the direction of one of University’s oldest scientific schools, chronobiology and chronomedicine (dynamical and rhythmic processes in our body and in the environment, in conjunction with human health). Currently in Russia there are no specialized journals devoted to biological clock, chronobiology and chronomedicine, the role of the time factor and rhythmicity in the diverse processes of nature and living systems. Worldwide there are several international journals devoted to rhythmic processes in living organisms, among which are the Journal of Biological Rhythms, Chronobiology International, Biological Rhythm Research, and Journal of Circadian Rhythms. Nonetheless, there is not a single periodical that is dedicated primarily to chronomedicine. We set ourselves the goal to evolve this journal in this direction under the new title «Journal of Chronomedicine». For the first issue of the Journal of Chronomedicine, the team of the Tyumen State Medical University and the Editorial Board dedicate this paper to commemorate two significant dates, namely the 90th anniversary of the founder of the Tyumen school of chronobiology, one of the first researchers of biological rhythms in ontogenesis, the founder of the Department of Biology of the Tyumen Medical University, Gubin Gennady Dmitrievich (b. 20.08.1928) and a very recent Grand Jubilee, the 100th anniversary of the birth of Franz Halberg, the founder of modern chronomedicine (b. 5.07.1919).
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ВЫДАЮЩИЙСЯ УЧЕНЫЙ ХРОНОБИОЛОГ, НАСТАВНИК И УЧИТЕЛЬ ГУБИН ГЕННАДИЙ ДМИТРИЕВИЧ
стр.6-7
The first issue of the Journal of Chronomedicine, formerly Tyumen Medical Journal, the team of the Tyumen State Medical University and the Editorial Board dedicate to two remarkable Jubilees - the 90th anniversary of the founder of the Tyumen school of Chronobiology, one of the first researchers of biological rhythms in ontogenesis, the founder of the Department of Biology of the Tyumen Medical University, Gennady Gubin (b. 20.08.1928) and a very recent magnificent Jubilee, the 100th anniversary of Franz Halberg, one of the founders of modern chronomedicine (b. 5.07.1919). Introducing the articles of the this first issue, most of which are devoted to the scientific heritage of these two outstanding scientists, one of the most fruitful students of Gennady Gubin, today a prominent Tyumen scientist and biographer, author of multi-volume encyclopedias «Keeping grateful memory», Nikolai Prokopiev shares his memories of the teacher.
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ФАКТОРЫ, КОТОРЫЕ НЕОБХОДИМО УЧИТЫВАТЬ ПРИ РЕШЕНИИ ПРОБЛЕМЫ АДЕКВАТНОГО КОНТРОЛЯ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ
стр.8-13
Губин Д.Г., Корнелиссен Ж.
Many physicians still believe that single blood pressure (BP) measurements provide reliable information for diagnostic purposes and treatment decisions. However, already 40 years ago, long before ambulatory BP monitoring became available, it was recognized that such strategy is nearly equal to flipping a coin and may end up in over 40% of false diagnostic conclusions (Management Committee, Australian National Blood Pressure Study, 1980). Today we know much more about BP variability (BPV). Plenty of factors heavily influence BP (irrespective of the device doctors or patients are using to measure BP). Not only are BP values influenced at the time of measurement, BPV and circadian characteristics of BP have also been shown to be affected. A significant role is played not just by time of the day (circadian phase and amplitude) but also by rhythms of some other frequencies, for example, the 12-hour and about-weekly components. In addition, timing determines not only how high or how low blood pressure is at this very moment, but also the derivative parameters of its variability. The purpose of this mini review is to give a schematic but dense idea of why single measurements of blood pressure are not informative, and even often misleading. The presented information should be used primarily by general clinicians, cardiologists, as well as specialists involved in the development of telemedicine technologies and the concept of personalized medicine.
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ТОЧНОСТЬ БИОЛОГИЧЕСКИХ ЧАСОВ, ХРОНОТИП, ЗДОРОВЬЕ И ДОЛГОЛЕТИЕ
стр.14-27
Губин Д.Г., Коломейчук С.Н.
Предложено обоснование взаимосвязи между точностью хода циркадианных биологических часов, хронотипом и здоровьем. На примере разных видов животных, а также человека, показано, что близкий к 24 часам циркадный период (tau) ассоциирован с продолжительностью жизни и, вероятно, присущ преимущественно обладателям умеренного утреннего хронотипа. Точный tau способствует поддержанию высокой амплитуды циркадианных ритмов, фенотипическому признаку, тесно связанному со здоровьем и долголетием. Рассмотрены некоторые генетические факторы, координирующие tau и обеспечивающие точный ход биологических часов (БЧ).
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ГЕНЕТИЧЕСКИЕ ОСНОВЫ ФОРМИРОВАНИЯ ГОЛОВНОГО МОЗГА КРЫСЫ В ПЕРИОД ЭМБРИОГЕНЕЗА
стр.28-31
В настоящей работе проведен анализ и обобщение данных литературы о генетических основах формирования головного мозга крысы в период эмбриогенеза. Схема активации генов в некоторой степени весьма сходна для человека и некоторых животных, что позволяет использовать полученные в эксперименте сведения для последующих клинических исследований.
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ФОРУМ В ЕКАТЕРИНБУРГЕ
стр.32-35
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