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PSYCHOLOGICAL CONDITION OF PATIENTS AFFECTS THE INTENSITY OF PAIN AFTER MAJOR UROLOGICAL SURGERIES
стр.1-3
Boyarkina A. V., Potapov A. L., Babanin A. A.
An observational study has been conducted aimed at evaluating the effect of preoperative psychological state on pain intensity after major urological surgeries. It has been determined, that the level of preoperative anxiety and depression is associated with the pain intensity after the surgery. In the group of patients with clinical anxiety/depression the maximal level of pain on the fi rst day after the surgery was 8-9.5 points, in the group of subclinical anxiety/depression 6-8 points, and in the group with no anxiety symptoms 5-6 points (p < 0.005). Moreover, signifi cant differences in the duration of maximal pain level and some other of its characteristics have been revealed between the groups.
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FEATURES OF CHRONIC VIRAL HEPATITIS C IN PREGNANT WOMEN
стр.4-6
Boyko V. O., Naumenko V.I.
A clinical and laboratory examination of 73 pregnant women with chronic viral hepatitis C has been performed. The study has clarifi ed the dominant ways of disease transmission, clinical and laboratory features of chronic viral hepatitis C, its negative infl uence on the pregnancy course with possible complications at the early and late stages of pregnancy. We have substantiated the need for regular examinations aiming to detect the markers of the viral hepatitis C in order not only to reduce the incidence of complications of pregnancy but also to prevent perinatal transmission of the virus.
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PARAMETERS OF SIMPLE AUDIO-MOTOR REACTION AS ONE OF POSSIBLE INDICATORS OF THE CENTRAL NERVOUS SYSTEM SENSITIVITY TO COSMOPHYSICAL FACTORS: GLOBAL AND LOCAL EFFECTS
стр.7-9
Khorseva N. I., Grigoryev P. Ye., Kilessa G.V., Ovsyannikova N. M., Glivenko A. V., Pobachenko S. V., Sokolov M. V.
For the fi rst time an analysis of simple audio-motor reaction (reaction time, the number of missed and delayed reactions) in individuals living in different latitudinal and longitudinal regions of Russia and Ukraine was carried out. During of magnetic storm main phase, a statistically signifi cant (p
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EVALUATION OF THE IMMUNE SYSTEM AND ENDOGENOUS INTOXICATION IN CHILDREN WITH ATOPIC DERMATITIS
стр.10-13
Kobets T. V., Gostishcheva E. V.
The study was conducted to examine the information, content, and predictive value of integrated leukocyte indices in assessing the level of endogenous intoxication of 118 children with atopic dermatitis. The study showed a comprehensive evaluation of hematological indexes is more informative than the study of a simple blood count. It allows you to assess the extent and severity of the infl ammation and endogenous intoxication, the immune system, the effectiveness of the therapy and to defi ne a strategy for further correction treatment. Also, the immune system was evaluated by the level of IL-1, IL-2, IL-4 and IL-6 in serum. In the period of exacerbation of the disease was an increase in the level of IL-1β, IL-4 and IL- 6, blood indices. After one month of treatment there is a tendency to reduce pro-infl ammatory cytokines, blood indices thought, despite the clinical improvement, therapy is still to be continued.
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The epidemiology of vestibular dysfunction in women with perimenopausal period
стр.14-17
Korsunska L. L., Meshcheryakova A. V.
The article presents some aspects of comprehensive assessment of the epidemiology of the vestibular dysfunction in women at perimenopausal period, with consideration of the fl ow of advanced reproductive disorders and medical correction of dyshormonal states as a background. We have analyzed the structural features of the dizziness syndrome in terms of women’s “hormonal continuum” and the impact of different techniques and forms of hormone replacement therapy on the characteristics of the clinical picture, with consideration of the vestibular dysfunction.
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EFFICIENCY OF CALCIUM CHANNEL-BLOCKER AMLODIPINE IN HEMODIALYSIS PATIENTS
стр.18-20
Krutikov E., Sakhaltuyev A., Polskaya L., Polishyk T., Shaknazarov A.
The purpose of the study was to estimate cardiohaemodynamic and anti-infl ammatory effects of treatment with use of Amlodipine in patients with the end-stage renal insuffi ciency who are on a program hemodialysis. 27 patients with arterial hypertension and ischemic heart disease have been taken Amlodipine as a monotherapy. We have studied the dynamics of the arterial blood pressure, the frequency and duration of ischemic episodes, the levels of pro-infl ammatory cytokines and C-reactive protein (CRP). We have established that four-week monotherapy with Amlodipine results in stabilization of the arterial blood pressure, decrease of frequency of ischemic attacks and activity of infl ammatory process in the majority of the patients. The use of Amlodipine leads to a decrease in the level of pro-infl ammatory cytokines after two and four weeks of treatment, the CRP level is signifi cantly decreased after four weeks of treatment. The antihypertensive and antianginal properties of Amlodipine in patients receiving hemodialysis therapy are predominate in comparison to its anti-infl ammatory effects.
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The neurocognitive dysfunction in adult patients with bipolar I disorder type
стр.21-23
Maruta N. A., Verbenko V. A., Verbenko G. N.
To study the strategies of optical and spatial activities, perceptual integrity of perception in patients with bipolar I disorder type - and analyze the effectiveness of pharmacotherapy. The initial analysis revealed impairment in executive functioning, modalityunspecifi c disorders of selective memory and attention in both manic and depressed bipolar patients. These disturbances are, in neuropsychological aspect, pathognomonic for dysfunction of the right hemisphere of the brain on the background of the left hemisphere’s general hyperactivity [8, 9]. Patients with inadequate response to treatment (a mood stabilizer, an antidepressant) showed signs of dominance of right and bilateral functional disorders of the brain.
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The state of the sympathoadrenal and vagoinsular systems in men of mature age, who suffer from allergic dermatoses
стр.24-27
The state of sympathoadrenal and vagoinsular systems was estimated in 80 men of different age: healthy men and men who suffer from allergic dermatosis were among them. Daily urinary excretion of adrenaline, noradrenaline, DOPA, dopamine, the levels of insulin and cortisol in the blood serum were studied. The decrease of activity and reserve capacity of sympatho-adrenal system as well as acceleration of biosynthesis of catecholamines at the stages of transformation DOPA in dopamine and dopamine in noradrenaline was fi xed in patients, who suffer from allergic dermatoses. High level of strain of glucocorticoid function of adrenal glands and the increase of activity of vagoinsular system, which are combined with the retardation of sympatho-adrenal system; signifi cant disturbances of vegetative homeostasis; reduction of activity of compensatory organism reactions was fi xed in patients who suffer from allergic dermatoses. Identifi ed violations substantiate the expediency of carrying out the corrective measures on the improvement of metabolism in brain in men aged 45-64 years as well as the need in the use of pharmaceutical products, which improve metabolism in brain, in patients who suffer from allergic dermatoses.
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STATISTICAL ANALYSIS OF TERRITORIAL DIFFERENTIATION OF MORBIDITY IN THE AUTONOMOUS REPUBLIC OF CRIMEA
стр.28-31
Ovsyannikova N.M., Mahkamova Z.R., Golubova T.N.
Using the K-means cluster analysis we analyzed morbidity rate in the regions of the AR of the Crimea and defi ned territories relatively similar on structure and level of morbidity. The comparison of clustering results showed that the group with a higher morbidity level was traditionally represented by cities. Medium and low levels of morbidity were identifi ed on rural territories. To make complex analysis, identify causes of morbidity changes, work out preventive measures and effective management decisions in health care it is necessary to include in statistical analysis other indicators of health: the mortality rate, the incidence rate etc.
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Immunohistochemical features of endometrial receptor system with unmaturing of pregnancy in patients with hyperprolactinemia
стр.32-35
Trushkevich A. A., Filonenko T. G., Golubinskaya E. P., Braude I. E., Stepur A. A.
Common morphological features of miscarriage are a low level of activity of invasive cytotrophoblast against reduction of the utero-placental barrier and increased hypoxia, which leads to degeneration and necrotic processes in the decidua and chorionic villi. The damage of large decidual cells accompanied by vacuolization of the cytoplasm causes reduction of the level of estrogen, progesterone and prolactin receptors and may cause abortion. Frustrated miscarriage is morphologically characterized by a pronounced infl ammatory response and a presence of fi brinoid necrosis. Immunohystochemical analysis in this study also proves that pregnant women with treated original hyperprolactinemia have a regular decrease of the hormone receptors. The level of estrogen, progesterone and prolactin receptors is considered as low according to the H-score. A critically low immunohystochemical reaction occurs only in cases of anembrionia, which is an unfavorable sign in the development and progression of subsequent pregnancies.
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BONE REMODELING: CELLULAR-MOLECULAR BIOLOGY AND CYTOKINE RANK-RANKLOSTEOPROTEGERIN (OPG) SYSTEM AND GROWTH FACTORS
стр.36-44
Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and maintain mineral homeostasis. In addition to the traditional bone cells, osteoblasts, osteoclasts and osteocytes, that are necessary for bone remodeling several biological active factors have also been implicated in bone disorders. This review discussed physiologic bone remodeling outlining the traditional bone biology dogma in light of emerging role growth factors data. Specifi cally discussed in detail are the cellular and molecular mechanisms of bone remodeling, including events that orchestrate the role cytokine RANK-RANKL-OPG system and growth factors of bone remodeling.
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