Крымский журнал экспериментальной и клинической медицины

The article is devoted to studying of the biological effects after parenteral injection of xenogenic cerebrospinal fluid. It was found that cerebrospinal fluid preparation caused different inhibiting effects on function of rats’ reproductive system in mature period, which is associated with the presence of broad spectrum of biological active substances in mammalian cerebrospinal fluid and its complex effects on recipients’ neuroimmunoendokrine regulatory system.

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Parameters of cardiovascular system of boarding-school pupils were studied depending on influence of extrinsic (ecological) and intrinsic (educational) medium factors. One found unfavorable influence of failed ecological medium on adolescents adaptation and negative influence of intensified educational loading on the pupils’ cardiovascular system function.

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We conducted an investigation of bacterial resistance in intensive critical care unit. There are a manifest prevalence resistance and poliresistance nosocomial bacterial floras. The most effective antibiotics were karbapenems and aminoglycosides. The maximal resistance was determined towards beta-laktams and fluoroquinolones.

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We have analyzed the results of clinical examination of patients after dental implants having been made non-removable dentures made of various materials (group 1 - metal-ceramic prostheses, group 2 - all-ceramic prostheses). Most favorable clinical picture of studing was observed in patients with non-metal ceramic dentures fixed on titanium implants. We used immunomodulator Erbisol that positively impacted on the timing of the adaptation of these patients after prosthesis regardless of the material fixed restorations in each group of patients (subgroup B) were treated with.

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It has been shown, that in the erythrocytes of patients with cardiomyopathy the content of glucose is rised and the tendency of increase of glycosilated hemoglobin is observed. At the same time, the glycolitic reactions of glucose utilization in erythrocytes are intensificated and it can has compensatoric significance.

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Due to stimulation of heterospecific immunity annual inoculations from a seasonal flu reduce probability of sharp respiratory viral infections on 38.7%. On a background negative attitude of mass media toward a vaccination, the study of all positive effects of vaccines is necessary. It is needed to report about results not only to the medical workers but also to all population.

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Structure and peculiarities of drugs adverse reactions (ADRs) in elderly age patients living in Crimea are analyzed in the article. In 2007 100 (17.5% from total amount) ADRs reports were eligible for analysis. Most frequently severe ADRs were registered in women and manifested as skin allergic reactions, they were caused by hypotensive drugs and required intensive medical correction. Drugs caused ADRs were prescribed per os. Analysis revealed many cases of irrational drug prescription. The research makes it possible to define frequent mistakes and to formulate practical recommendations how to prescribe drugs in elderly age patients rationally.

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In 122 human embryos in the age from 21 day to 12 weeks of the intrauterina development, which includes stage X - XXIII and beginning of the fetal period by classification of Carnegie institute, differentiation speed and organic individual formation of epithelium and mesenchyme derivatives of pancreas have been studed. Accounting the statistic criterions and the two- factual analysis karyometric data were studed. There are an essential differences in the age of differentiation stages in epithelium and mesenchyme derivatives of pancreas. 50 - 57 days and 10 - 11 weeks are the most important in the pancreas embryogenesis.

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We examined 108 patients with LC, mainly alcoholic etiology. Patients were conducted once or twice the definition of bactericidal activity of blood serum, the standard bacteriological examination of blood, as well as in blood serum levels of interleukin-1б and granulocyte-colony stimulating factor. The results of our study demonstrate that the stability of bacteremia is inversely proportional increase bactericidal activity of blood serum the with respect to S. aureus and E. coli. With increasing disease duration and frequency of recurrence decreases cytokine synthesis by inhibition of functional activity of the immune system.

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The article analyzed the clinical effectiveness of phosphatidylcholine liposomes in treating patients with liver cirrhosis. The results indicate that the use of phosphatidylcholine liposomes with a wide spectrum of pharmacological effects, have a positive impact on the basic parts of peroxide processes.

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The contemporary data on etiology, diagnosis and treatment of MVP are presented in the article. The stratification of risk for complications and sudden cardiac death in MVP is represented.

The article describes clinical and topographic features of the defects of the alveolar process connected with the lower nasal passage. There is no systematization of the surgical treatment of the defects and technical difficulties in the plastics of the defects of the lower nasal passage. The special method of plastics of the defects of the alveolar process is suggested, that gives possibility to use the membrane of the defect for this purpose.

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The dynamics of treatment of patients is studied with chronic general catarrhal gingivitis by complex and traditional methods. Due to the use of clinical, functional and biochemical research methods these treatments are got by complex and traditional therapy. Holiatry, plugging in itself preparations of «Biotrit», «Biodent-3» and ultrasonic skaler «R-takh» resulted in convalescence 19 from 25 patients, that was 74,4%. For patients, gettings traditional therapy, an improvement was observed in 25,5%.

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Increased functional activity of mesangial cells ifluenced by 40% ethanol leads to an uneven thickening of the glomerular basement membrane, mainly due to collagen type IV and increased mesangial matrix, resulting in violations of the kidney filtration barrier.

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Influence of X-ray therapy on the state of proteinase-inhibitor potential of the blood of 64 patients with malignant tumors of different localization it was investigated. Cancer in organism results in increase activity of proteinases and their inhibitors in the blood and level of this activity not dependent from tumor localization. Trypsin-like activity and level of б-1-proteinase inhibitor are most sensitive to X-ray therapy. Their reactions depended from initial state and shows a tendency to the normalization at efficiency of X-ray therapy.

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The article is devoted to the modern situation of prevalence and course of candidiasis, co-operation of this fungi with the different links of immunity. Debatable moments, touching diagnostics and treatment of patients with these mycosis, are lighted up.

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Research on studying of influence of electromagnetic radiation of devices of mobile communication on change of activity of antibodies and antigenes of systems of blood types АВО and Rh is conducted. By results of studying of indicators control and skilled groups change of an indicator of activity of the Β-antigene, D - an antigene and β - antibodies is authentically established

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Authors describe an unstable epidemiological situation on Laim’s diseases in territory of the Dnepropetrovsk area. Studying of epidemiological and clinical features of a clinical course Laim’s diseases in the city of Dnepropetrovsk was the work purpose. It is studied level of disease and the data of the clinikoepidemiological analysis for 2006-2009 is presented. Authors note increase in disease by Laim’s, prevalence erytematous forms though at the present stage are registered also atypical disease forms.

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В статье освещаются вопросы морально-этического воспитания в медицинских ВУЗах. Формирование у студентов этических принципов должно стать стержнем профессионального и морального воспитания будущих врачей. А нализ результатов анонимного анкетирования младшекурсников, выпускников и интернов относительно вопросов врачебной этики выявил недостаточный уровень информированности будущих врачей о современном мировом состоянии этой проблемы, науке биоэтике и ее месте в системе медицинских и биологических наук. Анализ ответов респондентов позволяет авторам сделать вывод, что в медицинский вуз приходит молодежь, которая имеет моральные установки, адекватные профессии врача. В процессе обучения молодежь приобретает специальные знания, но ее социализация происходит в условиях морального кризиса общества, и влиянию среды должно противостоять в полной мере морально-этическое воспитание.

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The authors have studied the left ventricular myocardium of persons who died suddenly of noncardial causes and who did not suffer from cardiac disease, as well as patients who died of diabetes mellitus of type 2. A set of lectins Sumbucus nigra, Weat germ, Peanut, Laburnum anagyroides and Lens culinaris lectins were used. A natural redistribution of the number of receptors of four of five investigated lectins in the endothelium of blood capillaries of the left ventricular myocardium in diabetes mellitus occur. Diabetic cardiomyopathy essentially changes the number of lectins binding sites in vascular endothelium and results in a reduction of sialo- and N-acetyl-D-glycosamincojugates (Weat germ lectin binding sites) in the cytoplasm of contractive cardiac muscle cells and L-fucosocojugates (Lens culinaris lectin binding sites) in nuclei of these cells.

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There is data about high informativity of SCT in diagnostic of changes in bones and soft tissue structures in cases of Osteochondrosis of cervical part of the spinal column with contrast usage which allows to improve the visualization of anatomical structures of spinal column and paravertebral region. It has a prominent role in efficiency estimation of sanatorium-resort rehabilitation of patients and individualization of treatment methods.

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The questions of specific of doctor’s activity are examined in the article. A brief review of legislation concerning the informed consent to medical intervention is given in the article. The variant of the informed consent to scheduled orthopedic operation is submitted. The main theses of documents «The Consent to a complex of medical interventions» and «The Information for a patient» are considered. The approximate algorithm of doctor’s actions during informing the patient about scheduled medical intervention is given and the process of receipt of the written consent of the patient is described.

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The article is about of possibility of diagnostic mistakes based on findings of modern investigations only, when clinical manifestations of malignant tumors are not considered.

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The article reports on the new recommendations of the European Association of Cardiologists management in patients with atrial fibrillation. This document reflects the evidence-based medicine data, obtained during a series of international studies on the problem of fibrillation atria, which were published in the period 2006- 2010.

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The review present modern ideas about place early using of physical therapy in complex rehabilitation patients with vertebral osteochondrosis with neurological manifestations.

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This article discusses the role of structural defects in the connective tissue matrix as a locus of primary neurovascular and neuroendocrine interactions. Processes occurring in the connective tissue matrix, along with other interacting abnormalities, are considered to be pathological substrate of neurocirculatory dystonia.

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Virus encephalitis in children begins acutely, proceeds severe. Coma, convulsive syndrome, meningeal and focal symptoms were characterized by completeness and stability of displays. In 9 patients after the transferred disease the residual phenomena are marked. Encephalitic reaction in children has developed on a previous neurologic background, etiological factor the sharp respiratory virus infection has served. Disease began acutely and proceeded severe. In a clinical picture the convulsive form has come, clinical symptoms of damage of nervous system (meningeal, focal and general brain) differed short duration and incompleteness of the clinic, full clinic-laboratory recovery) in all surveyed patients without the residual phenomena. These clinical distinctions can serve as differential-diagnostic criteria between virus encephalitis and encephalitic reaction.

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Analysis of students’ motivation for admission, further doctor speciality selection and ethical principles is discussed in the article. 82 second year students of medical university were asked by special questionnare. Conclusion: to get strong qualified doctors in future it is necessary to carry out tests and take into account applicants moralities and knowledge about ethical behavior in different situations.

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Установлено, что поражения диэнцефальной зоны при гриппе, которые характеризуются как гриппозный диэнцефалит, возникают, как правило, спустя 1-1,5 месяцев, после перенесенного гриппа, и, как правило, самостоятельно проходит через 2-3 недели. Для данной патологии являются характерными отдельные или сочетанные явления: астения, гипертензия, гипотония, сердцебиение, приступы ознобов, анорексия, булимия, нарушения жирового обмена, терморегуляции, боли в области сердца, импотенция.

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The differences of parameters infradian rhythmicity of regenerative processes in planarians with different functional asymmetry. Electromagnetic shielding causes changes infradian rhythmicity that animals with different functional asymmetry expressed in different ways.

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