Крымский журнал экспериментальной и клинической медицины

The paper presents an analysis of the results of the treatment of warty form of leukoplakia in 27 patients who were divided into 3 groups. A comparative clinical and cytological assessment of the effectiveness of cryosurgery and conservative treatment with Solcoderm and Solkovagina. Application of the proposed drugs allowed to completely eliminate the lesion with minimal side effects, to achieve normalization of keratinization of the epithelium RBCU expressed remission. The results obtained allow to recommend the use of Solcoderm Solkovagina and in treatment of warty form of leukoplakia.

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Analysis of using creative therapy of patients with disturbances of psychical sphere in a structure of rehabilitation programs are analyzed. Influences of complex biopsychosocial reabilitation are studied on quality of life, cognitive functions and efficiency of treatment for patients, sufferings from schizophrenia.

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In this paper were studied relations of psycho-emotional parameters with change geliometeofactors within 30 days. The subjects, which are characterized by strong emotional experiences in the performance of mental work, motor and social passivity were most sensitive to the factors of space weather and the least - to weather conditions. The subjects, which are characterized by high motor and mental capacity, a wide range of communication programs had the smallest number of correlations between psycho-emotional indicators and heliogeophysical and meteorological factors. The subjects to be highly anxious, emotionally unstable with increased nervousness showed the greatest sensitivity to change of geliometeofactors. A feature of this group was the response ahead of 1-2 days at changing of geliometeorological factors.

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Posterior encephalocele surgical treatment optimization at newborns is studied. 8 urgent operations were executed on the offered methodology (Copyright №35210). Preparation of elements of hernia sack for the plastic arts, expansion of defect of skull in area of hernia gate was conducted. Following sparing « telescopic» immersion of the contained hernia sack in a hernia gate was executed with « spreading» of incrassate pia mater encephali under the unsealed dura mater encephali on the edge of defect of skull, the plastic arts of the extended hernia gate and defect of skull by the mobilized dura mater encephali with further closure-seal by the skin-fascia layer transposition. At newborn the offered methodology gives an only opportunity to conduct the sparing plastic arts of encephalocele any the form and sizes in the conditions of soft tissues hypotrophy without excision of hernia sack and it content (cerebral tissue, sines, ventricle), with the minimum risk of intraoperative blood loss and postoperative complications.

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Treatment of hypertension in patients with bronchial asthma is a difficult task. The choice of antihypertensive drugs is limited due to the negative effect on аirway. This article shows the advantage of purpose angiotensin converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers for the treatment of hypertension when combined with bronchial asthma.

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The method of restoration treatment passive vertical spine-traction іn water is offered at by the help of aquabelt in combination with a aquagymnastic. At 94,3% from 114 patients with chronic dorsalgia the considerable improvement of the state on the indexes of pain syndrome, mobility and muscle force of spine and extremities was registered (in control - at 41,7% from 36 patients).

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According to the literature, have established presence of correlation interrelation between smoking and change of a condition of a mucous membrane of an oral cavity. Changes extend on microbic flora, biochemical structure of an oral liquid and a hygienic condition.

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It is carried out morphological research of hearts of 24 porpoises with experimental bronchial asthma, 6 ones received metabolic therapy. Firm character of morphological changes in conditions of this experiment testifies to necessity of basic therapy in the period of clinical remission.

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Quantitative maintenance of circulatory immune complexes (CIС) was studied in the blood of women with physiological pregnancy and of pregnant women with different degree of preeсlampsia before and after treatment in order to Ministry of Health of Ukraine and after complex treatment for gestosis is produced by authors. It was estimated an increase of level of CIС according the preeсlampsia progress. After standard treatment the level of CIС did not decrease, and exceeded initial values. After the complex treatment for gestosis is proposed true level of CIC decrees was estimated, the positive results were proved by gestosis improvement or non-progressing of preeclampsia.

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The effect of long-time tobacco smoking upon systemic cytokine capacity was investigated in patients with chronic obstructive pulmonary disease and chronic heart failure. It is established the significant increase of systemic proinflammatory cytokine activity - levels of TNF-α, IL-1β, and IL-6 - in smokers.

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In the article morphological cardiovascular system analyzed the experimentally caused juvinal rheumatoid arthritis on the 24 white breed «Wistar» rats. Laboratory research done allowed to level concentration cardiamarkers troponin I and aminoterminal bruin natriuretic peptide (ТнI и NT proBNP) in serum of blood of juvenil rheumatoid arthritis are revealed and dystrophy and disturbance of cardiovascular system of this experiment testifies to necessity of metabolic correction.

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Pursuant to to information of literature, set that at child’s cerebral paralysis in a kind the defeats of both central (oblong brain) and peripheral link of the stress-realizing system (GGNS). For patients, sufferings this syndrome, the process of intravital develops vital dizadaptation. The process of acclimatization for them takes place not only in the conditions of sanatorium-resort treatment (new places of inhabitation) but also in the usual for them terms of residence.

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On the basis of clinical and cytological study of 23 patients with chronic lip fissure was traced solcoseryl effectiveness of such drugs as Solcoseryl Ointment and Solcoseryl dental adhesive paste. The normalization of the cytological pattern in specimens from patients in parallel with clinical recovery, advancing the application of Solcoseryl dental adhesive paste in a total of 1-2 days faster, indicating that most of its effectiveness compared with Solcoseryl-ointment.

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For the first time pH-distribution of IgG-molecules of blood serum, which have different types of light chains and its change according to the peculiarities of a disease of thyroid gland, was studied. IgG, taking part in the immunocomplex, has its own individual peculiarities with respect of light chains of its molecules according to autoimmune diseases of thyroid gland and pH-zone of distribution of isoelectric fractions (at isoelectric focus).

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Inherent marble-bone disease behaves to the number of rare diseases. Exact lifetime recognition of inherent marble-bone disease on the basis of polymorphic clinical displays is almost impossible, in any event, always unreliably. The diagnosis of marble-bone disease can be set only after roentgenologic research of all skeleton Treatment of inherent marble-bone disease is taken to one only symptomatic measures

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The strategic tasks of educating of medical radiology of students are considered on the credit-module system. One of them are a complex study and optimization of educational process with clear distribution of points of progress. Extracurricular selftraining of students goes into detail; the value of standardization and objectivism is certain during realization of FMK, that has a practical orientation foremost, that is important at forming of modern doctor.

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The article is devoted one of the global medical and social problems - prevention of stroke in patients with atrial fibrillation. The data on the introduction of amendments to the recommendations for prevention thromboembolic events in AF at the XII Congress of Cardiology in Ukraine. This report included a recommendation on the feasibility of using inhibitors of factor Xa (rivaroxaban, apiksaban) to prevent stroke in all patients with atrial fibrillation.

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Tubulointerstitial changes are the important sign of chronic renal diseases progress and can be characterized by the infiltration of interstitium, sclerosis of stromal tissue and the atrophy of tubular epithelium. A key role in development of this process is devoted to the interstitial miofibroblasts and tubular epithelia cells.

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This article describes a rare case of ectopic pregnancy in the contralateral to the ovary uterine tube. Risk factors and preventive measures of development of this pathology were analyzed.

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To one of the most global and real threats in realization of concept about a favourable and safe environment, both in our country and in the world, there is drug addiction. Pharmacy drug addiction is the least studied, but no less dangerous phenomenon in modern society. The anonymous questionnaire of student middle schools is conducted Simferopol for the purpose adherence to the healthy way of life and presence of harmful habits, inspection 500 narcodependent people in Crimea after 2010. Age-dependent, sexual composition of people of liable is in-process described to such drug addiction. In-use medicines which require hard pharmaceutical control are described. Described complication at the use of the indicated medicines. The methods of decision of problems are offered related to pharmacy drug addiction.

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Strong anti-oxidant activity of polyphenols counteract with free radical oxidation component of the chronic ischemic hart disease pathogenesis. Grape’s polyphenols food concentrate ENOANT was used in complex recuperative treatment of patients with chronic ischemic hart disease. The ENOANT enables more effective realization of seven clinical goals, including coping with stress and avoid of distress, improving in external breath pattern and oxygen capacity of blood, diminishing in complications of gas-exchange and hemodynamics failure, enlarge in detoxic reserves and antioxidant potential, improving in lipids and other endogenous factors, increasing in tolerance to physical exercise.

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Histological and electron microscopic research of pulmonary specimens of 19 patients with a viral inducted acute respiratory distress syndrome who died on the 2nd - 19th day of disease’s course was performed. It was determined that during first 2 - 3 days the major changes had been associated with development of a diffuse alveolar damage. Proliferation of the alveolar epithelium had been appeared on 4th - 5th day and fibrosis that was associated with the formation of intra alveolar exudate and the generation of collagen fibres in the interstitium of lungs’ respiratory part, had been observed at the end of 2nd week of pathologic process.

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In the article describe the analysis of the level of motivation, intelligence, and aggressiveness, which was into comprehensive program of tolerance education among students, helped remove uncertainty in the understanding of the list of the values , and increase the number of motivated students. Intellectual resources, as an ability to navigate in difficult situations, to focus on the moment with regard to clearly defined purpose, helped to students curb aggressive tendencies.

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In the article the questions of biological compatibility of alloys of orthopedic constructions are considered; it has been revealed that metal ions dissociating into the oral liquid from metal constructions of dentures activate the processes of free radical oxidation. Thus the the increase in catalase activity and decrease in activity of б-amylase of mixed saliva are observed.

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Cytokines level in cultural medium of mononuclear leukocytes kind was studied at patients with chronic pulmonary and chronic heart insuffitiency.Long-term smoking experience was determined to be charakterised by increased plasmin-induced synthesis of mononuclear leukocytes of proinflamatory TNF-α, cytokines.This state forms the conditions for chronization and progression of pathological process.

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The article is dedicated to methods of surgical preparation of pressure ulcers for future radical defect closure. Methods are stratified according to depth and area of skin defects, and nearness of anatomic structures. Authors demonstrate expedience of all the methods in different clinical situations on 64 patients with pressure ulcers of different localizations.

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The article provides an overview of contemporary literature, allows to distinguish common aspects of the pathogenesis of generalized periodontitis and the metabolic syndrome. Actuality of this problem, the need for further study.

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In the article the morphological variety of tumours of ovaries in accordance with existent classification is represented.

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Polymorphism of human populations for mutant alleles of genes responsible for the work of the human immune system, leading to the development of vaccine-related complications, of which a few decades ago did not know anything, or they were very rare. Due to the fact that Russia has not conducted a mandatory mass screening of population for HIV infection, and teach the patient is not always aware of his HIV status, there is a risk of posvaktsinalnyh complications associated with both dissimination living component of the vaccine, and to provoke the development of AIDS antigenic stimulation of the inactivated vaccine component.

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В статье идет речь о важности роли мужчин в вопросах отцовства, их влияние на воспитание детей и здоровье партнерши, их собственное здоровье, об их объединяющей роли в семьи и положительное влияние на партнерские отношения.

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Now there is great anthropogenic chemical and bacterial pollution of health resort resources, it can give degradation sanitation quality of resorts and violation of the health of the population and recreants. In these conditions it is necessary to develop new scientific direction “Recreational ecology”, it main problems are: elaboration monitoring system pollution of recreational resources, reglamentation pollutants in resort objects, investigation influence of resort pollution at sanitation effect of resort treatment and health of recreants, elaboration program of actions for protection resorts from pollution. It is necessary to create scientific and practical center of resort ecology.

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Unsatisfactory results of surgical treatment of patients with peritonitis, force the specialist to search for the new approaches to decision of the specified problem. Constantly the search of new solutions goes for sanacii of abdominal region. In basis of suggestions of application of solutions for sanacii of abdominal region, the satisfied lies of that a «abdominal cavity at the poured out festering peritonitis is a large abscess («total abscess» of abdominal cavity)», which must be treated on all laws of festering surgery. Pushing off from it we in an experiment intraabdominal applied water-soluble unguent at peritonitis. It is set that intraabdominal application of water-soluble unguent on our method, possesses high efficiency in regard to a bacterial flora, does not render the nativelyirritating action on fabrics and mezoteliy of peritoneum, instrumental in the rapid clearing of abdominal cavity.

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The study is devoted to the experimental form of focal encephalitis, as a fundamental principle of brain abscesses. Studied stage of cerebral inflammation.

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There is powered exsvisitive observation of twenty years evagination of ascending colon through the cecostoma after resection of hepatic angle of the colon, combined with calculous cholecystitis and parastomatic hernia.

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The diseases of esophagus are varied, determined by wide prevalence, clinical meaningfulness and possibility of existence of the so-called extraesophageal displays. Therefore in all cases careful differential diagnostics is required taking into account clinical and roentgenologic signs.

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Research is devoted to the study of the clinical-diagnostic and therapeutic peculiarities in patients with gunshot wounds of the spine and spinal cord. It was noted that, with gunshot injuries of the cervical spine more than half the patients observed anatomical or «axonal» break the spinal cord.

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In the article set out a review of different author’s data about morphological and functional changes in tissue structures of the kidneys in acute and chronic alcohol intoxication, revealed the diversity, absence of common views on the pathogenesis of lesion tissue structures of the kidneys in alcohol intoxication. The perspectives of further research in this area were determined.

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The review deals with issues of treatment of patients with genotype 1 chronic hepatitis C with new antiviral drugs that direct action, which are inhibitors of the protease NS3.

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The article is devoted to the study of mechanisms of effect of metal alloys of orthopedic constructions on oral tissues, as well as on oral liquid.

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Целью любого исследования при выявлении узлового образования в Щ.Ж. является решение вопроса о дальнейшей тактике ведения больного: наблюдение, консервативное лечение или хирургическое вмешательство. Окончательное решение, как правило, зависит от выяснения вопроса о доброкачествен-ном или злокачественном характере опухоли, функциональном состоянии выявляемого узла, оценки размеров узла, выраженности компрессии им трахеи, пищевода, сосудисто-нервного пучка.

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Особые формы хронического гастрита, как правило, не имеют клинических проявлений и не нуждаются в симптоматическом лечении, а скорее требуют выработки определённой тактики наблюдения, кратности осмотра и морфологической динамики, в конечном итоге определяющей тактику ведения больных.

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